Part I: Advanced Arthritis Imaging in Clinical Practice.
- Chapter 1 Technical Considerations for Clinical MRI of Arthritis
- Chapter 2 Functional Anatomy and Structure of the "Osteochondral Unit".
- Chapter 3 Clinical MRI of Osteoarthritis and Osteochondral Injury.
- Chapter 4 Surgical Approaches for Osteochondral Repair and Postoperative Imaging Considerations.
- Chapter 5 Ultrasound Evaluation of Rheumatoid Arthritis.
- Chapter 6 MRI in Rheumatoid Arthritis.
- Chapter 7 Nuclear (Scintigraphic) Methods and FDGPET in Rheumatoid Arthritis and Osteoarthritis.
Part II The Future of Advanced Imaging in Arthritis.
- Chapter 8 New MRI Techniques for Osteoarthritis.
- Chapter 9 Molecular Imaging of Rheumatoid Arthritis and Osteoarthritis.
Index.
Arthritis in Color: Advanced Imaging of Arthritis reviews the state of the art as well as current research and recent advances in the use of MRI, ultrasonography, computed tomography (CT), and nuclear and molecular imaging (MI) for the diagnosis and treatment of arthritis, especially rheumatoid arthritis (RA) and osteoarthritis (OA). The first section of the book focuses on the clinical state of the art, emphasizing methods that are currently available and in routine clinical use throughout the world; the second portion is forwardlooking and emphasizes new and experimental methods and imaging strategies, including cutting-edge molecular imaging research, which is the topic of the final chapter.
Arthritis is a leading cause of disability worldwide. OA is the most common type of arthritis, affecting an estimated 20.7 million adults in the United States alone (U.S. Government data). RA is a generally more serious and debilitating disease, affecting more than 10 million persons of all ages in the United States. These diseases are among the most significant causes of disability in our society, with costs in lost work and productivity estimated at over $1 billion annually. As our world population ages, the impact of arthritis on the human condition, quality of life, and world economy will take on an even larger and increased significance.
In recent years, conservative management of arthritis has been replaced with new, aggressive drug therapies. These, in turn, have created an unprecedented demand for more rapid assessment of disease activity and response to treatment. Necessity is, as is often said, the mother of invention—but in a very real sense today’s arthritis patients benefit from a lucky convergence of advances in imaging technology (that have coincidentally occurred in time to be of use) and new biopharmacologic therapies.
More powerful drugs offer new hope for relief but have also created significant new challenges for physicians and pose some risks for patients. The pharmaceutical industry has invested heavily in developing new drugs for arthritis, and articles in the Wall Street Journal* and other financial and business sources have speculated that drugs targeted to joint diseases—and especially RA—will become the premier growth market for the pharmaceutical industry, attracting considerable capital for research and development in both traditional and newer biotechnology firms.
These new disease-modifying and biologic response-altering drug therapies are extremely aggressive by historical standards in rheumatology; accordingly any sort of rapid assessment “feedback” that can be provided is of great value both to guide the clinician and to help justify the risks and expense involved in their use. Traditional radiographs, while still the mainstay of diagnosis and classification of disease, are insufficient for this purpose. Conventional radiography is limited in that it depicts the complex soft tissue changes in arthritis only in terms of the presence or absence of gross swelling and the bony changes only as the cumulative sum of the long-term effects of disease activity (e.g., the development of permanent bony deformities, such as osteophytes, joint subluxations, and erosions). To assess the severity of disease or response to treatment, radiographs essentially require a large number of observations (i.e., serial imaging at intervals), with painstaking comparison of the progression of small or subtle deformities observed over an extended period of time—and even when done meticulously and rigorously will provide only a very limited and incomplete portrayal of the dynamic disease processes involved in the complex, chronic disease entities as they affect an individual patient.
Because of these limitations, radiology researchers have turned their efforts toward adapting newer, advanced imaging methods and technologies toward the assessment of articular cartilage in OA and for assessment of disease activity by various means in inflammatory arthritis (mostly RA and related diseases). Gaining an understanding and mastery of these methods and their implications going forward is both a difficult challenge and a tremendous opportunity for the field of diagnostic radiology. Integrating these new methods rationally into the day-to-day management of patients is the 21st century challenge to the field of rheumatology.
This book is intended as a resource for both fields, and its goal is to efficiently and comprehensively educate diagnostic radiologists, rheumatologists, and other specialists as to the state of the art, current methodologies, and future research directions in this dynamic and rapidly evolving arena. In doing so, from a huge and rapidly growing volume of clinical and research literature in the field have drawn —some quite recent and some published over the past 2 decades or more—in an attempt to provide a broad perspective on the field, as well as to distill a refined elixir of the most salient facts, organized in such a way as to make the topic as clear and as simple as possible.
The title of this book was intended as an homage to the now classic radiology textbook from which so many of us learned the plain film diagnosis of the arthritides, Arthritis in Black and White, by Drs. Anne Brower and Donald J. Flemming, soon to be in its third edition. This landmark text, which to this day remains an intellectual staple and bedrock textbook for both radiologists and rheumatologists, is by no means diminished by our efforts here. To the contrary, the new textbook to build upon the solid foundation of Arthritis in Black and White, and to provide in this volume a resource have attempted that will serve as a logical continuation on the topic of imaging in arthritis for the interested reader at all levels of professional training and experience.
Key Features
- Provides correlation images that depict the disease process on ultrasound, MRI, and plain radiographs to allow you to confirm a diagnosis quickly and easily.
- Explores MRI and ultrasound as more effective approaches to diagnosing rheumatoid arthritis and osteoarthritis due to their superior evaluation of soft tissues, marrow, and cartilage.
- Features more than 600 digital quality images300 in full colorthat clearly illustrate the material being presented.
- Includes examples of pathology with color illustrations to help you arrive at more accurate diagnoses.
- Covers both basic and advanced concepts for a well-rounded, well-balanced approach suitable for the novice or the expert.
- Presents the expert guidance of Michael A. Bruno, Gary E. Gold, and Timothy J. Mosherinstructors of the popular annual course at the American Roentgen Ray Society on Advanced Imaging in Arthritisfor a consistent, accessible style.
About the Authors
- Michael A. Bruno, MD, Director of Quality and Safety; Associate Professor of Radiology and Medicine, Department of Radiology, Pennsylvania State University College of Medicine, Hershey, PA.
- Gary E. Gold, Assistant Professor of Radiology, Stanford University School of Medicine, Stanford, CA.
- Timothy J. Mosher, Associate Professor of Radiology and Orthopedics, Chief, Musculoskeletal Imaging, MRI, and Radiology Research, Department of Radiology, Pennsylvania State University College of Medicine, Hershey, PA.
Book Details
- Hardcover: 236 pages
- Publisher: Saunders; 1 edition (May 27, 2009)
- Language: English
- ISBN-10: 1416047220
- ISBN-13: 978-1416047223
- Product Dimensions: 10.4 x 7.4 x 0.6 inches
List Price: $113.00
The Fifth Edition of MRI of the Musculoskeletal System provides significant updates on principles, techniques, and applications for musculoskeletal imaging.
