Molecular Imaging: Radiopharmaceuticals for PET and SPECT

Radioisotope-based molecular imaging probes provide unprecedented insight into biochemistry and function involved in both normal and disease states of living systems, with unbiased in vivo measurement of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology including functional magnetic resonance imaging (fMRI) can provide such high sensitivity and specificity at a tracer level. The applications of this technology can be very broad ranging from drug development, pharmacokinetics, clinical investigations, and finally to routine diagnostics in radiology. The design and the development of radiopharmaceuticals for molecular imaging studies using PET/MicroPET or SPECT/MicroSPECT are a unique challenge.
This book is intended for a broad audience and written with the main purpose of educating the reader on various aspects including potential clinical utility, limitations of drug development, and regulatory compliance and approvals.

Hybrid PET-CT and SPECT-CT Imaging: A Teaching File

With clinical cases related to multiple clinical entities presented in depth, Hybrid PET-CT and SPECT-CT Imaging: A Teaching File by Dominique Delbeke and Ora Israel is designed to be a teaching manual and everyday companion for our colleagues working in private practice, for residents training in nuclear medicine or radiology, for medical students, and for physicians whose specialties carry over into molecular imaging with radiopharmaceuticals.
The first two chapters cover the technical aspects of hybrid imaging and a historical perspective of the development of this technology. Recommendations for patient preparation and acquisition protocols, with special emphasis on physiologic variants, pitfalls, and artifacts follow. The next 15 chapters are devoted to clinical applications in oncology, according to specific malignant diseases and patient populations. The final three chapters present relatively new clinical applications of hybrid imaging in the field of cardiology, skeletal, and infectious diseases.
Each chapter begins with a succinct summary of the recent literature for the specific clinical application. This is followed by a series of case presentations ranging from the simple to the more complex in an attempt to simulate clinical practice. Images are presented in PET/SPECT stand-alone, CT stand-alone, and fused-images format in order to highlight the advantages and incremental value of the hybrid technology in the cases selected. At the end of each chapter, up-to-date references allow the reader to follow in greater depth the rapidly expanding volume of knowledge.
Contents 
Part I General
I.1 History and Principles of Hybrid Imaging
I.2 Normal Distribution, Variants, Pitfalls, and Artifacts
Part II Clinical Applications in Oncology
II.1 Tumors of the Central Nervous System
II.2 Hybrid Imaging of Head and Neck Malignancies
II.3 Lung Cancer
II.4 Breast Cancer
II.5 Colorectal Cancer
II.6 18F-FDG PET/CT in Tumors of the Gastrointestinal Tract: Esophageal and Gastric Cancer and Gastrointestinal Stromal Tumors (GIST)
II.7 Hepatobiliary and Pancreatic Malignancies
II.8 Gynecological Tumors
II.9 Hybrid Imaging in Malignancies of the Urinary Tract, Prostate, and Testicular Cancers
II.10 Thyroid Cancer
II.11 Endocrine Tumors
II.12 Lymphoma
II.13 Melanoma
II.14 Malignancy of the Bone: Primary Tumors, Lymphoma, and Skeletal Metastases
II.15 Pediatric Applications for PET/CT and SPECT/CT
Part III Other Clinical Applications
III.1 Cardiac Hybrid Imaging (PET/CT and SPECT/CT): Assessment of CAD
III.2 Hybrid Imaging of Benign Skeletal Diseases
III.3 Infectious and Inflammatory Diseases
Subject Index 

Product Details

• Hardcover: 762 pages
• Publisher: Springer; 1st  edition (November 23, 2009)
• Language: English
• ISBN-10: 0387928197
• ISBN-13: 978-0387928197
• Product Dimensions: 10.1 x 6.9 x 1.5 inches

Mettler Essentials of Nuclear Medicine Imaging 5th edition

• Ch. 1 Radioactivity, Radionuclides, and Radiopharmaceuticals.
• Ch. 2 Instrumentation.
• Ch. 3 Quality Control.
• Ch. 4 Cerebrovascular System.
• Ch. 5 Thyroid, Parathyroid, and Salivary Glands.
• Ch. 6 Cardiovascular System.
• Ch. 7 Respiratory System.
• Ch. 8 Gastrointestinal Tract. .
• Ch. 9 Skeletal System.
• Ch. 10 Genitourinary System and Adrenal Glands.
• Ch. 11 Conventional Neoplasm Imaging and Radioimmunotherapy.
• Ch. 12 Genitourinary System.
• Ch. 13 Inflammation and Infection Imaging.
• Ch. 14 Legal Requirements and Radiation Safety.
• Self Evaluation Section.
• Unknown Case Sets.
• Answers to Unknown Case Sets.

Appendices.

• A. Characteristics of Radionuclides for Imaging Therapy.
• B-1. Radioactivity Conversion Table for International System (SI) Units (Becquerels to Curies).
• B-2. Radioactivity Conversion Table for International System (SI) Units (Curies to Becquerels).
• C-1. Technetium 99m Decay and Generation Tables.
• C-2. Iodine 131 and Strontium 89 Decay Charts.
• D. Injection Techniques and Pediatric Dosage.
• E. Sample Techniques for Nuclear Imaging.
• F. Non-radioactive Pharmaceuticals in Nuclear Medicine.
• G. Pregnancy and Breastfeeding.
• H-1. General Considerations for Patients Receiving Radionuclide Therapy.
• H-2. Special Considerations and Requirements for Iodine 131 Therapy.
• I. Emergency Procedures for Radioactive Spills.

Index.

Essentials of Nuclear Medicine Imaging 5th edition by Fred A. Mettler and Milton J. Guiberteau has established itself as the best introduction to nuclear imaging techniques. It is practical, yet comprehensive, covering physics, instrumentation, quality control, and legal requirements. The 5th Edition features a new color format, with many user-friendly features such as "Pearls and Pitfalls." More than 600 pictures in digital-quality resolution depict imaging of each body system. A series of Unknown Case Sets, with answers, help test your knowledge.


Book features:

• Includes helpful appendices including Injection Techniques, Pediatric Dosages, Non-radioactive Pharmaceuticals, and many more.
• Presents important "Pearls and Pitfalls" in each chapter.

New in this edition:

• Features a new full-color format making information easy to read and find.
• Covers new techniques such as PET/CT, cardiac-gated SPECT, and tumor-specific radionuclides.
• Provides full-chapter coverage of hot topics such as:
• Cerebrovascular System.
• Cardiovascular System.
• Conventional Neoplasm Imaging and Radioimmunotherapy.
• Positron Emission Tomography Imaging.
• Includes seven complete Unknown Case Sets for self-testing.

About the Authors

• Fred A. Mettler, Jr., MD, MPH, Professor and Chair, Department of Radiology and Nuclear Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM. 
• Milton J. Guiberteau, MD, Professor of Clinical Radiology, University of Texas Medical School at Houston; Chairman, Department of Radiology, St. Joseph's Hospital, Houston, TX.

Book Details

• Hardcover: 592 pages
• Publisher: Saunders; 5 edition (November 23, 2005)
• Language: English
• ISBN-10: 0721602010
• ISBN-13: 9780721602011
• Product Dimensions: 10 x 8 x 0.8 inches

List Price: $106.00