BOLD fMRI: A Guide to Functional Imaging for Neuroscientists

Functional magnetic resonance imaging (fMRI) represents one of the most advanced and enlightening functional imaging techniques that has ever been developed. One major area of research interest in fMRI is within the field of Cognitive Neuroscience, which focuses on understanding all aspects of the mental processes involved in awareness, reasoning, and acquisition of knowledge and behavior. This book includes selected chapters from Functional MRI: Basic Principles and Clinical Applications (S. Faro and F. Mohamed, Eds. New York: Springer Science+Business Media, LCC 2006) that the editors feel are of particular interest to neuroscientists, as the focus is primarily on describing the basic principles of Blood Oxygen Level Dependent (BOLD) imaging and the developing clinical applications of fMRI in the neurosciences.
The first section of the book is an introduction to the physics principles of BOLD imaging as well as a review of fMRI scanning methodologies, data analysis, experimental design, and clinical challenges. The second section reviews some current and future clinical applications of fMRI, including the clinical fields of Language, Memory, fMRI WADA, and Brain Mapping. The third and final section is a pictorial neuroanatomical atlas of the basic motor, sensory, and cognitive activation sites within the brain. This section will give neuroscientists a familiarity with some of the more clinically relevant brain activation sites that are discussed in other chapters.
There has been a discovery of a tremendous body of knowledge in the relatively young field of fMRI.

fMRI - Basics and Clinical Applications

Within the past two decades, functional magnetic resonance imaging (fMRI) has developed tremendously, from initial descriptions of changes in blood oxygenation that can be mapped with MRI (Ogawa) using T2*-weighted images to very basic investigations performing studies of the visual and motor cortex. From there, it has further evolved into a very powerful research tool and has also become an imaging modality of daily clinical routine, especially in presurgical mapping. This book focuses on these clinical applications starting from the basics and the backgrounds leading to current concepts and their application in a clinical environment.
It is interesting to see how fMRI became a clinical application over recent years of which the neurosurgeons were very suspicious in the initial phase of first clinical experiments in presurgical mapping. Its acceptance can be recognized based on increased numbers of studies performed on demand.
With this book the author try to answer some questions and give an overview on how fMRI can be applied for clinical purposes.

Contents
Section 1 Basics
1 Introduction
2 Neuroanatomy and Cortical Landmarks
3 Spatial Resolution of fMRI techniques
4 The Electrophysiological Background of the fMRI Signal
5 High-Field fMRI
6 Press Button Solutions
Section 2 Clinical Applications
7 Preoperative Blood Oxygen Level Dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) of Motor and Somatosensory Function
8 The Functional Anatomy of Speech Processing: From Auditory Cortex to Speech Recognition and Speech Production
9 Use of fMRI Language Lateralization for Quantitative Prediction of Naming and Verbal Memory Outcome in Left Temporal Lobe Epilepsy Surgery
10 Mapping of Recovery from Poststroke Aphasia: Comparison of PET and fMRI
11 Functional Magnetic Resonance-Guided Brain Tumor Resection
12 Direct Cortical Stimulation and fMRI
13 Imaging Epileptic Seizures Using fMRI
14 Special Issues in fMRI-Studies Involving Children
15 Multimodal Brain Mapping in Patients with Early Brain Lesions
16 Combining Transcranial Magnetic Stimulation with (f)MRI
17 Clinical Magnetoencephalography and fMRI
Index

Book Details

• Authors: Stephan Ulmer and Olav Jansen
• Hardcover: 181 pages
• Publisher: Springer; 1 edition (December 10, 2009)
• Language: English
• ISBN-10: 3540681310
• ISBN-13: 978-3540681311
• Product Dimensions: 10.4 x 7.8 x 0.6 inches