- 1 Casting Light on Neural Function: A Subjective History.
- 2 Fluorescent Sensors of Membrane Potential that Are Genetically Encoded.
- 3 The Influence of Astrocyte Activation on Hemodynamic Signals for Functional Brain Imaging.
- 4 Somatosensory: Imaging Tactile Perception.
- 5 How Images of Objects Are Represented in Macaque Inferotemporal Cortex.
- 6 Optical Imaging of Short-Term Working Memory in Prefrontal Cortex of the Macaque Monkey.
- 7 Intraoperative Optical Imaging of Human Cortex.
- 8 Using Optical Imaging to Investigate Functional Cortical Activity in Human Infants.
- 9 In Vivo Dynamics of the Visual Cortex Measured with Voltage Sensitive Dyes.
- 10 Fast Optical Neurophysiology.
- 11 Two-Photon Laser Scanning Microscopy as a Tool to Study Cortical Vasodynamics Under Normal and Ischemic Conditions.
- Index.
These include the techniques of intrinsic signal optical imaging, near-infrared optical imaging, fast optical imaging based on scattered light, optical imaging with voltage sensitive dyes, and two-photon imaging of hemodynamic signals. The purpose of this volume is to capture some of the latest applications of these methodologies to the study of cerebral cortical function.
This volume begins with an overview and history of optical imaging and its use in the study of brain function. Several chapters are devoted to the method of intrinsic signal optical imaging, a method used to record the minute changes in optical absorption due to hemodynamic changes that accompanies cortical activity. Since the detected hemodynamic changes are highly localized, this method has excellent spatial resolution (50–100 µm ), a resolution sufficient for visualization of fundamental modules of cerebral cortical function. This methodology has led to huge advances in our understanding of cortical function and is now being used intraoperatively to study function and dysfunction (such as epilepsy and stroke) in human neocortex.
At even higher spatial resolution, in vivo two-photon imaging permits incredible visualization of responses within cortical columns and within microvascular compartments. Other rapidly developing optical technologies and their applications are also introduced. Near-infrared imaging, also hemodynamically based, is particularly well suited for studying brain function in infants and children due to its noninvasiveness and ease of use. High temporal resolution optical imaging, capable of following neuronal activity on the millisecond timescale, is achieved with methods such as voltagesensitive dye imaging and imaging based on scattered light signals.
Together, this volume provides a cross section of the current state of optical imaging methodologies and their contribution towards our understanding of the spatial and temporal organization of cerebral cortical function.
Key Features
- Encapsulates the current state of optical imaging methodologies.
- Contributes to our understanding of the spatial and temporal organization of cerebral cortical function.
About the author
- Dr. Anna W. Roe is a professor of psychology and radiology at Vanderbilt University. She has developed optical methods for studying brain function and specializes in how our brain builds real vs. illusory percepts of the world.
Book Details
- Hardcover: 259 pages
- Publisher: Springer; 1 edition (October 29, 2009)
- Language: English
- ISBN-10: 1441904514
- ISBN-13: 978-1441904515
- Product Dimensions: 9.3 x 6.2 x 0.8 inches