Molecular imaging has been employed in many fields. It combines the disciplines of molecular biology, radiochemistry, pharmacology, instrumentation, and clinical medicine into a new imaging paradigm. In particular, molecular imaging plays an important role in drug discovery and advanced medical practice. Serial assessments of molecular and cellular function are commonly used as surrogate markers of various new treatments. In this sense, molecular imaging has developed in parallel with the progress of drug development and new medical treatments.
Hokkaido University has launched the Matching Program for Innovations in Future Drug Discovery and Medical Care. This program aims to establish a center for drug discovery and medical care through molecular imaging technologies. The central pillars are our world-leading technologies in glycoprotein pharmaceuticals and optical and positron emission tomography (PET) imaging technology. The program helps our university contribute to society by improving the quality of life for patients, by creating new industries that use novel technologies, and by fostering internationally minded innovators who are able to launch new businesses. Placing particular importance on industry-academia collaboration, we have also established the Frontier Research Center for Post-Genome Science and Technology, as well as the Research Center for Cooperative Projects. With the creation of these facilities, the establishment of a core organization for drug discovery and medical care has been greatly promoted.
They have had an international symposium together with leading world specialists regarding molecular imaging for integrated medical therapy. The symposium “Molecular Imaging for Integrated Medical Therapy” held March 13–14, 2009, at Hokkaido University, Sapporo, Japan, was a joint symposium of “The 6th Symposium for Future Drug Discovery and Medical Care” and “Symposium of the Research Center for Cooperative Projects”. At the symposium, more than 150 physicians and scientists attended to share our new experiences in molecular imaging for drug development and advanced medical therapy.
Contents
Advances in Molecular Imaging
PART I NEW MOLECULAR IMAGING AND IMAGE-GUIDED RADIOTHERAPY
Hokkaido University has launched the Matching Program for Innovations in Future Drug Discovery and Medical Care. This program aims to establish a center for drug discovery and medical care through molecular imaging technologies. The central pillars are our world-leading technologies in glycoprotein pharmaceuticals and optical and positron emission tomography (PET) imaging technology. The program helps our university contribute to society by improving the quality of life for patients, by creating new industries that use novel technologies, and by fostering internationally minded innovators who are able to launch new businesses. Placing particular importance on industry-academia collaboration, we have also established the Frontier Research Center for Post-Genome Science and Technology, as well as the Research Center for Cooperative Projects. With the creation of these facilities, the establishment of a core organization for drug discovery and medical care has been greatly promoted.
They have had an international symposium together with leading world specialists regarding molecular imaging for integrated medical therapy. The symposium “Molecular Imaging for Integrated Medical Therapy” held March 13–14, 2009, at Hokkaido University, Sapporo, Japan, was a joint symposium of “The 6th Symposium for Future Drug Discovery and Medical Care” and “Symposium of the Research Center for Cooperative Projects”. At the symposium, more than 150 physicians and scientists attended to share our new experiences in molecular imaging for drug development and advanced medical therapy.
Contents
Advances in Molecular Imaging
PART I NEW MOLECULAR IMAGING AND IMAGE-GUIDED RADIOTHERAPY
- Hypoxia Imaging for Image-Guided Radiotherapy
- Molecular Imaging for the Assessment of Tumor Malignancy and Response to Therapy
- Development of a Prototype 3D PET Scanner Using Semiconductor Detectors and Depth of Interaction Information
- A New PET Scanner with Semiconductor Detector Reveals Intratumoral Inhomogeneous Cell Activity with High Spatial and Energy Resolution
- A New Positron Emission Tomography (PET) Scanner with Semiconductor Detectors for Target Volume Delineation and Radiotherapy Treatment Planning in Patients with Nasopharyngeal Carcinoma
- Initial Performance Measurement of an Integrated PET/SPECT/CT
- System for Small-Animal Imaging
- Molecular Imaging of Atherosclerotic Plaque Vulnerability: Comparison between 18F-FDG and 99mTc-annexin A5
- Quantification of Myocardial Blood Flow Using Rubidium-82 PET
- New Concepts for Molecular and Functional Imaging of the Heart: Implications for Regenerative Treatments
- Molecular Imaging of Angiogenesis
- Spontaneous In Vivo Regeneration of the Articular Cartilage Using a Novel Double-Network Hydrogel
- Bone Marrow Stromal Cell Transplantation for Central Nervous System Disorders: Perspectives for Translational Research and Clinical Application
- Noninvasive Optical Tracking of Bone Marrow Stromal Cells Transplanted into Rat Cerebral Infarct
- Thermoreversible Gelation Polymer (TGP) Hydrogel as a Degradable Scaffold for Bone Marrow Stromal Cell Transplantation
- Beneficial Effects of Bone Marrow Stromal Cell Transplantation on Axonal Regeneration in Injured Spinal Cord
- Transplanted Bone Marrow Stromal Cells Improve Cognitive Function after Diffuse Axonal Injury in Rats
- Ultra-High Throughput Screening (uHTS) Chemical Genetics to Identify Novel Chronotherapeutics
- Cell Death and Autophagy
- Bioluminescent Imaging for Assessing Heterogeneous Cell Functions in the Mammalian Central Circadian Clock
- Early Postnatal Stress and the Serotonergic System in the Brain
- Neural Circuit Development and Plasticity Shaped by Glutamate Transporters
- Molecular and Functional Imaging for Drug Development and Elucidation of Disease Mechanisms Using Positron Emission Tomography (PET)
- The Sea as a Source of New Drugs
- PET/AMS Applications in Drug Development
- Functional and Structural Analysis Reveals Dual Function on C-Terminal a Helix of Alg13 Protein
- Discovery of a First-in-Class Drug, a Prostaglandin D2 Antagonist, for the Treatment of Allergic Diseases
- Towards Developing a Golgi Simulator: Microfluidic Device Enabling Synthesis of a Tetrasaccharide
- An Efficient Strategy for the Exploration of Specific Inhibitors of Sialyltransferases